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Results Search and risk of bias Of the 54 articles assessed for eligibility, 23 RCTs (References 123 in the Additional file 1) fulfilled the inclusion criteria and were included in the meta-analysis (Additional file 1: Fig

Phase 2 Confirmatory Dosing Data Phase 3 Standardized Dosing Regimens Current phase 3 trials employ standardized retatrutide dosing protocols: Retatrutide Dosing: Titration Protocols for Optimal Outcomes Standard Clinical Titration Schedule Gradual escalation is the cornerstone of safe retatrutide dosing : Accelerated Titration for Tolerant Subjects Conservative Titration for Sensitive Populations Retatrutide Dosing: Species-Specific Preclinical Protocols Mouse Models Allometric scaling consideration : Mouse retatrutide dosing at 0.3 mg/kg produces approximately human-equivalent exposure to 12 mg weekly when adjusted for metabolic rate and body surface area

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