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In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections

Of course, these were done with different drugs that were older drugs

Never, ever refreeze a thawed peptide solution

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Furthermore, incorporating drugs that consider individual-specific factors can yield benefits beyond glycemic control