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It is not intended as a starting dose or for patients who are already meeting their health goals on the lower dose

Several of the medications showed that patients with a history of cardiac disease or risk factors for cardiovascular disease had lower risks of heart attacks, strokes, and myocardial infarctions when taking these agents compared to patients taking standard of care regardless of A1C lowering [35,36,37]

Similar benefits were seen with calorie restriction, suggesting that weight loss may have been a major contributing factor for these effects

What is the shortest effective treatment duration

Long-term, prospective studies are still needed, Hardaway said