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Different strains have a different impact, too

Key timeline for Eli Lillys orforglipron: The approval of the first oral GLP-1 pill for weight loss expands the treatment landscape for obesity

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The latter includes both central homeostatic (energyintakefocused) and nonhomeostatic (rewardfocused) regulation of food consumption in the hypothalamus and nucleus of the solitary tract [268, 269, 270, 271], influenced by a relatively small amount of GLP1 that crosses the bloodbrain barrier and, more notably, GLP1 modulation of vagal afferent neurons [268]