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Most NAION cases reported in clinical studies occurred within the first year of semaglutide use, suggesting a drug-induced effect related to treatment initiation or rapid metabolic changes

Diseases such as celiac disease, scleroderma, and Crohns disease can increase the risk of developing SIBO due to their effects on gut motility and function

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Thus, HO-1 induction in cancer cells may inhibit the haem-mediated dimerization of PGRMC1 through the production of CO and thereby suppress tumour progression

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