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Both compounds face absorption challenges, but for different reasons

The OLE aglycone has anti-aggregation activity against the aggregation of both aggregation of A42 and pE3-A, together with reducing the expression of the enzyme, and interferes with pE3-A formation due to glutaminyl cyclase

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Phosphatidylethanolamine-binding protein 1 (PEBP1) and arachidonate 15-lipoxygenase (ALOX15) can interfere with phospholipid alcohol synthesis and induce ferroptosis [5, 52]

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