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The first GLP-1 receptor agonist, exenatide, was approved by the FDA in 2005 to help treat Type 2 diabetes

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Modulations of gene expression related to inflammatory signaling, angiogenic regulators, cell cycle control, and structural matrix proteins have been documented in preclinical and in vitro systems

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If the vial was at room temperature (2025C) for 812 hours, it has likely lost 1520% potency but remains safe to use if no visible contamination is present