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All in all, both retatrutide and Mounjaro appear safe and well-tolerated for most people, with manageable side effects
Semaglutide versus placebo in patients with heart failure and mildly reduced or preserved ejection fraction: a pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM randomised trials
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The clinical significance hasnt been characterized
Challenges persist, however, including regulatory scrutiny across different regions concerning health claims, competition from established oral supplements and injectable GLP-1 agonists, and the need for robust clinical validation to support efficacy claims for topical applications
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