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"If the regained weight is disproportionately fat, individuals may ultimately be worse off than before in their fat-to-lean mass ratio, which may have adverse consequences for their health," said Brajan Budini, one of the study's investigators

At the maximum maintenance dose of 7.2mg per week, Wegovy can help you lose on average 21% of your initial body weight over 72 weeks

When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases

Advertisement This was the first cardiovascular outcome trial of an incretin-based therapy with an active comparator, notes Dr

The compound defends cells that secrete GLP-1 against damage that can sabotage production of the hormone