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This suggests the kidney problems may not be caused by the drug itself, but by dehydration related to side effects

daily oral), treatment duration goals, baseline health metrics, and provider clinical judgment

Alcoholism: Clin Exp Res

8.8%) These results are published in The New England Journal of Medicine (Wharton et al., 2025) and represent the strongest weight loss data ever seen from an oral GLP-1 candidate in Phase 3 trials

Consider increased clinical or laboratory monitoring for medications that have a narrow therapeutic index or that require clinical monitoring Use in Specific Populations Pregnancy: Available data with semaglutide use in pregnant women are not sufficient to determine a drug associated risk for major birth defects, miscarriage, or other adverse maternal or fetal outcomes