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One-way analysis of variance was applied to assess the color changes between the groups at different time intervals

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Overall, neonatal pain management and sedation encounter gaps in evidence and practice, emphasizing the need for standardization, improved personalized approaches based on pharmacokinetic and pharmacodynamic maturation, multimodal strategies to minimize opioid and benzodiazepine exposure, and rigorous studies of new therapies to ensure safe, effective, and equitable care for newborns