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This process prompts excess free radical production, as also observed in patients with T1D (Domnguez et al., 1998), while the accompanied hyperglycemic state may directly contribute to oxidative stress-induced organ damage (Maritim et al., 2003)

A study in patients with sepsis-associated acute kidney injury showed that glucocorticoid treatment was significantly associated with increased ICU and in-hospital mortality (Zhu X