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This effect is dose-dependent and typically more pronounced with immediate-release formulations compared to extended-release preparations

Owing to its favorable safety profile, SAMe may be specifically suitable for the treatment of MDD in children, adolescents, and pregnant women

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Materials and methods Oral carnitine challenge test The OCCT was performed through oral administration of 1500 mg of carnitine tablets (GNC) to the test participants

However, oral LC supplementation increases the levels of trimethylamine- N -oxide (TMAO) [12], which, as a pro-atherogenic factor, has been indicated to increase the risk of cardiovascular disease (CVD) [13], chronic kidney disease (CKD) [14], and even cancer [15]