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Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
4 The financialization of Big Pharma
GoodRx does not offer much of a discount on Wegovy for the uninsured
With the last expiring follow-on patent being in 2042, this amounts to a period of 49 years of patent protection in total
To break down what GLP-1s are, how they work, and who they might be right for, we sat down with Britleigh Garcia, PA-C, a clinician here at Nice Healthcare whos completed a certificate program in obesity management through the American Academy of Physician Assistants and The Obesity Society
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