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At least one serious adverse event occurred among 10.9% of the 36 mg orforglipron group, 10.3% of the 12 mg orforglipron group, 7.3% of those receiving 6 mg orforglipron and 8.8% of the placebo group

Stable transfection of SK-Hep LC cells with ATB0,+/ASCT2 antisense RNA-expressing plasmids resulted in a 73% reduction in ATB0,+/ASCT2 mRNA levels and a 65% reduction in the Gln transport rate, leading to a 98% reduction in cell number after 48 h

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