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It means that excess positive charge may trigger membrane lysis at increased peptide dosing

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BPC-157 and TB-500 are complementary regenerative peptides, BPC-157 dominates VEGFR2 angiogenesis and FAK-paxillin migration (tendon, GI healing), TB-500 dominates G-actin sequestration and stem-cell mobilisation (muscle and cardiac regeneration)

10.1136/gutjnl-2019-319104 10

Andersen KE & Rycroft RJG (1991) Recommended patch test concentrations for preservatives, biocides and antimicrobials