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8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs

Reconstitution requirements GHK-Cu typically comes lyophilized (freeze-dried) and requires reconstitution before injection

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Since its very hard to get an accurate measure of B12 in people, the researchers instead searched for levels of methylmalonic acid (MMA) as its levels rise when B12 levels decrease