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When side effects might signal a problem

Skipping meals or trying extreme diets or detox trends can backfire by slowing metabolism and increasing hunger pangs

115 , 116 Similarly, in 150 women with infertility and letrozole resistance, threemonth treatment with either metformin (1500 mg/day) or inositol, both with folic acid, showed no significant effect on ovarian function or pregnancy rate compared with folic acid alone, though inositol was more effective than metformin in women with normal BMI

Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network metaanalysis of randomised controlled trials

I mean, it is from, I think, 2019, when the popular book was published