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A 15% change in IGF-I (g l 1 ) corresponded to a 0.35 change in IGF-I SDS

This system is not just a transport mechanism

Studies have shown that significant concentrations of lixisenatide were found in the brain of mice 30 minutes and 3 hours after intraperitoneal injection, suggesting that lixisenatide could cross the BBB (125)

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Building upon these primary results, we further assessed the robustness of these associations through a comprehensive series of sensitivity analyses and meta-analysis