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The relationship between varicocele and spermatogenic impairment is strongly supported by clinical and experimental evidence, particularly through oxidative stress, inflammatory cytokines, blood-testis barrier disruption, and germ-cell injury

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(2020) 72:1052A3A

found a negative correlation between serum zinc levels and the severity and extent of vitiligo [99]

Although these studies are published in indexed journals, independent replication by other research groups remains insufficient to draw definitive conclusions about therapeutic efficacy in humans