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For SSRIs, benefit increases up to about 2040 mg/day fluoxetine equivalents, while discontinuation due to adverse effects increases with dose

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USA 116 , 358366 (2019)

For those with controlled diabetes, moderate alcohol consumption may not significantly alter blood sugar levels

PROTAC-based approaches have been developed to selectively degrade aggregation-prone proteins, including QC-01-C175 for tau in AD, XL01126 for LRRK2 in PD, and GW5074 for mutant huntingtin in HD