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These ingredients are chosen based on a patients response, lab values, and overall treatment strategy

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Thus, more mechanistic studies are needed to understand mechanisms by which indoxyl sulfate affects macrophage responses in CKD and to explore strategies to regulate macrophage phenotype in the high indoxyl sulfate milieu

For the assessment of kidney injury severity (severity score), HE stained section images at 10 and 20 (2 at each magnification, for a total of 4 images per mouse) were graded from 0 (no damage) to 5 (most severe damage observed across the samples analyzed), based on the following parameters: (i) protein cast formation, (ii) visible tubular dilation, (iii) loss of proximal tubular cell polarization (no visible brush-border membranes) (iv) area affected (with single nephron damage to majority of the cortex with visual signs of injury)

Carnitine may exist in two isomers, labeled D-carnitine and L-carnitine, as they are optically active