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The same 2017 study referenced above reported the following side effects in some participants who received 250mg of oral glutathione:6 Pruritis (itching) Macular erythema (rash-like red patches on the skin) Red spots on the skin Tiredness Transaminitis (high liver enzyme levels in the blood) Additionally, specific glutathione supplements may pose more safety concerns than others

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To address copper-dependent toxicity in WD in human liver cells, we reanalysed the RNA sequencing data (GSE107323) [2], validated gene expression signatures and functionally addressed our findings in the HepG2 ATP7B knockout (ATP7B-KO) model [7]