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This included circumvention of the complex downhill syndrome, as well as a sudden decrease of blood supply, decreased NO levels in the inferior caval vein tissue, an immediate heavy loss of endothelial cells from the vascular wall, a lower eNOS production ability (Rangan and Bulkley, 1993

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Analyses of the IBM MarketScan data were performed using R v4.1.0 and R studio 2022.02.3 software (R Foundation for Statistical Computing, Vienna, Austria), with R package survival for the time-series analysis and SAS OnDemand for Academics (SAS Institute, Cary, NC) for propensity score matching