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Conversely, a single-institution study of 1,191 participants failed to find a difference in the rate of new retinopathy or existing retinopathy progression between GLP-1/GIP agonist or SGLT2 inhibitors when the amount of hemoglobin A1c reduction was the same in the two treatment arms

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In fact, an adult may take doses up to about 2400 mg/day of ALA without severe harmful effects in the short term, although higher doses do not necessarily confer additional benefit