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The SURMOUNT program studied tirzepatide for weight management (NEJM, 2022) and SURMOUNT-OSA examined obstructive sleep apnea (NEJM, 2024)
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Supporting this, GIP knockout mice exhibit reduced hepatic steatosis and lower IL-6 levels when fed a high-fat diet, implicating GIP in inflammatory signaling within the liver [80]
Both these neuron systems express estrogen receptors: ER is predominantly expressed in the POMC (proopiomelanocortin) neurons, while both ER and ER are present in neuropeptide Y (NPY) and agouti-related protein peptide (AgRP) neurons (78, 79)
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