GSTP1 binds to mitogen-activated protein kinase JNK and inhibits JNK downstream signaling (159)
Nishijima titled Efficacy of Gastric Lavage in Acute Alcohol Poisoning, published in the Journal of Clinical Toxicology (2017), early gastric lavage improved short-term outcomes in 15% of cases when administered within 3060 minutes
Effect of pH on H 2 O 2 Production by GSH Quantification of H 2 O 2 production by 10 and 30 mM GSH at its intrinsic pH (5.4 and 3.3, respectively) and at pH 7 0.2 (buffered using NaOH) in 1 PBS was analyzed using a Hydrogen Peroxide Assay Kit (Fluorometric-Near Infrared) (Abcam, Australia) complemented with a fluorescence plate reader (Tecan infinite M1000 pro)
Glu is then converted to -ketoglutarate (-KG) via glutamate dehydrogenase (GLUD1), which enters the tricarboxylic acid (TCA) cycle (Yao et al., 2021), -KG accumulation promotes oxidative stress by enhancing ROS production and lipid peroxidation, thereby inducing ferroptosis (Gao et al., 2015)
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