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However, several considerations apply: Melanocortin receptor agonists could theoretically fall under prohibited substance categories if evidence of performance enhancement emerged Athletes should consult with sports medicine physicians and anti-doping officials before use Lack of current prohibition does not indicate WADA endorsement or recommendation Future regulatory status could change based on emerging evidence Availability and Compounding Considerations FDA-approved Vyleesi available only by prescription through licensed pharmacies Some compounding pharmacies offer PT-141, though quality, purity, and dosing accuracy may vary Research-grade PT-141 available from peptide suppliers for laboratory use only International regulatory status varies by country Research Classification: PT-141 is available in FDA-approved form (Vyleesi) for one specific medical indication by prescription only

Discussion As far as we are aware, this is the first investigation using MRS at 7T to study brain neurochemistry in patients with long COVID, and the second the first one being our pilot study [19] - in ME/CFS

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Refrain from other consumption for at least 30 minutes post-dose