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Albert Matheny , RD, CSCS, a co-founder of SoHo Strength Lab
No contraindications are documented for injectable use in domestic animals
Regardless of how quickly you observe results, Semaglutide is one of the most durable weight-loss drugs on the market
Sorensen G (2015) GLP-1 receptor agonist reduces cocaine self-administration
Real-World Examples: 250-Pound Person: Average loss: 56 pounds (22.5%) Final weight: 194 pounds Timeline: 18-20 months 200-Pound Person: Average loss: 45 pounds (22.5%) Final weight: 155 pounds Timeline: 18-20 months 300-Pound Person: Average loss: 67 pounds (22.5%) Final weight: 233 pounds Timeline: 20-24 months Dosing Schedule: Standard Escalation: Weeks 1-4: 2.5 mg weekly (starting dose) Weeks 5-8: 5 mg weekly Weeks 9-12: 7.5 mg weekly Weeks 13-16: 10 mg weekly (if tolerating well) Weeks 17-20: 12.5 mg weekly (if needed) Week 21+: 15 mg weekly (maximum dose for weight loss) Flexible Dosing: Not everyone needs maximum 15 mg dose Many achieve excellent results at 10 mg Provider adjusts based on results and tolerance Can stay at effective dose rather than pushing to maximum Side Effects: Most Common: Nausea: 30-37% (lower than semaglutide despite higher potency) Diarrhea: 19-23% Vomiting: 9-17% Constipation: 10-17% Abdominal discomfort: 8-11% Interesting Finding: Despite being more potent, tirzepatide causes less nausea and vomiting than semaglutide
