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11 It is worth noting that the induction of weight loss by incretin-based therapies is also dependent on additional mechanisms, such as decreasing gastric emptying, lowering food intake, and improving satiety ( Figure )
doi: 10.1037/amp0000059 [DOI] [PMC free article] [PubMed] [Google Scholar] 149.Volkow ND
Early results have made it a focus due to its impact on weight, blood sugar, and fat, particularly in adults with obesity or type 2 diabetes
5.1.2 Effects on pancreatic -cell glucagon release In addition to their insulinotropic effects on -cells, both GIP and GLP-1 play a role in regulating glucagon secretion of pancreatic -cells, with GIP increasing and GLP-1 suppressing glucagon secretion, both in a glucose-dependent manner
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