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The exposed surfaces of products may then discolour and crack, and in extreme cases, complete product disintegration can occur

30 Three phases of colchicine poisoning include: 30 Gastrointestinal phase (10 24 hours) including abdominal pain, nausea/vomiting and diarrhoea Multiorgan phase (2 7 days) can include a wide range of serious adverse effects including paralytic ileus, myopathy, myocardial toxicity and severe cardiovascular dysfunction, respiratory failure and blood dyscrasias Recovery phase in those who survive (within a few weeks) Colchicine is contraindicated in patients with severe renal or hepatic impairment, significant gastrointestinal or cardiac conditions or pre-existing blood dyscrasias

Beginners start at 5 mg once weekly for 2 weeks to assess tolerance, then can increase to 5 mg twice weekly (10 mg/week total) for performance goals

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