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Moreover, visceral fat is likely to return in anyone who discontinues their tesamorelin therapy, whereas patients whove taken semaglutide (e.g., Ozempic) have seen at least some longer-lasting health outcomes after ending their treatment.14 29 Therefore, there are three takeaways about tesamorelin and abdominal fat: Tesamorelin may be able to reduce your morbidity for serious chronic health conditions

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However, these effects are modest and should not be considered a replacement for prescribed medication

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The present systematic review was created by reviewers who searched PubMed, Web of Science, and Scopus databases, covering the period from January 1980 to March 2025