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307,330 In genetically modified mice expressing mutated Kras in pancreatic cells, repeated daily restraint stress or the administration of -adrenergic receptor agonists enhanced PDAC development, primarily through catecholamine signaling

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Falta de respuesta adecuada : Si despus de 3-6 meses de tratamiento a la dosis teraputica completa no se observan mejoras significativas en el control glucmico (reduccin de HbA1c de al menos 0.5-1%) o en el peso corporal (prdida de al menos 5% del peso inicial cuando se prescribe para manejo de peso), debe consultar con su mdico