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In step-c), Fmoc-Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-VaI-Ser(Oxa)-OH (fragment-2) was condensed with peptide obtained from step-b) in presence of a coupling agent to obtain Thr(tBu)-Phe-Thr(tBu)-Ser(tBu)-Asp(OtBu)-VaI-Ser(Oxa)-Ser(tBu)-Tyr(tBu)-Leu-Glu(OtBu)- Gly-Gln(Trt)-Ala-Ala-Lys(C18 diacid mono-t-butyI-y-Glu(AEEA-AEEA)-OtBu)-Glu(OtBu)- Phe-Ile-Ala-Trp (Boc)-Leu-Val-Arg (pbf) Gly-Arg (pbf)-Gly-OtBu peptide

It increases insulin secretion when blood sugar rises

Safety depends on the type of peptide, dosage, and individual health factors

Ensure that management by neonatology experts will be available at delivery [see WARNINGS]

Li J, O W, Li W, Jiang ZG, Ghanbari HA