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Section 3(f) of Executive Order 12866 defines a significant regulatory action as any regulatory action that is likely to result in a rule that may: (1) have an annual effect on the economy of $100 million or more or adversely affect in a material way the economy, a sector of the economy, productivity, competition, jobs, the environment, public health or safety, or State, local, or tribal governments or communities

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Fisher A, Pittel Z, Haring R, Bar-Ner N, Kliger-Spatz M, Natan N, Egozi I, Sonego H, Marcovitch I and Brandeis R (2003) Ml muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy

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