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Growing evidence now confirm that mature miRNAs are crucial for the fine-tuning of circadian rhythm regulations that also include sleep (Table 5 enlists some of the miRNAs reported to regulate Circadian Rhythm in different tissues)

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Activation of cell death pathways in the inner ear of the aging CBA/J mouse

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The clinical data gap should be interpreted cautiously given the difference in trial size (338 vs 2,539 participants) and development stage