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In constitutively fair skin, these processes are much less effective, and the resulting epidermal pigmentation is much less protective 47 , leaving the melanocytes vulnerable to direct absorption of ultraviolet radiationas happens in the C57BL/6-HGF mouse model

However, some studies demonstrated no increase in prevalence of colorectal cancer in patients or individuals with constipation ( Although this case cannot establish causality between MC and colon cancer, a high level of clinical vigilance for occurrence of colon cancer in patients with MC should be maintained

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16 Nicotine exposure via chewing tobacco has also been linked to decreased measures of sperm health and function

( We found that the GPX4 expression and ferrous iron levels were increased in 5-FU- or AZ628-derived tolerant CRC persister cells, which render persister cells sensitive to GPX4 inhibitors-induced ferroptosis