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Tirzepatide is a dual agonist, meaning it can bind to either receptor type

Mild gastrointestinal effects commonly occur during this period as the body adapts to GLP-1 receptor activation

For many patients, semaglutide is a reasonable starting point, particularly those newer to GLP-1 therapy or with a preference for the medication with the longest history of use

However, the evidence base for three times weekly sublingual dosing is thin compared to the robust clinical trial data supporting daily oral and weekly injectable protocols