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The cost of being wrong either entering too early and facing successful patent enforcement, or entering too late and ceding first-mover advantage is measured in hundreds of millions of dollars

Van Schaik L, Kettle C, Green R, Irving HR, Rathner JA (2021) Effects of caffeine on brown adipose tissue thermogenesis and metabolic homeostasis: a review

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The exact dosage should be determined by a healthcare professional based on individual health needs and goals