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2014 Jan 1;126(1):19-29

10.3389/fnut.2025.1566595 Front Nutr

Pullulan is an all-natural polysaccharide (a polymer in the carbohydrate family) obtained by fermentation of tapioca or cornstarch , using a strain of fungus (Aureobasidium pullulans)

Symptoms can be uncomfortable, and their inconvenient timing may feel out of control or even embarassing

It is inferred that the aggregation of sEVs during electroporation and the intraluminal space within sEVs, which is occupied by siRNA, is fully saturated, leading to the lower encapsulation efficiency of electroporation (130, 131)