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Glutaminase is actively expressed in periportal liver cells, renal epithelial cells, and the central nervous system, which is used to synthesize urea and neurotransmitters

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In mice lacking Nav1.6 channels, I NaP currents are reduced by 39%, and I NaR currents are suppressed by 76%, leading to the loss of subthreshold oscillations, impedance resonance, and both spontaneous and evoked rhythmic firing (Enomoto et al., 2006, 2007)