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Some patients need periodic dose adjustments if their appetite control shifts over months or years, while others find their ideal dose and remain stable for years

The researchers also uncovered a more encouraging trend

doi: 10.3390/ijms21207777 121

The European Society of Cardiologys 2022 guidelines, on the one hand, said withholding these drugs in hypertensive patients and patients without heart failure undergoing noncardiac surgery should be considered, in view of concerns about hypotension