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Although this is consistent and mechanistically validated across different preclinical models, as reviewed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section, the correspondence between NAD + changes and mitochondrial or metabolic alterations is more complex in human studies

Starting at the standard initiation dose is still recommended, but extending each escalation step to 6-8 weeks instead of 4 weeks is a common clinical adjustment

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This can make the test more accurate and prevent tampering

doi: 10.1007/s00726-013-1481-5