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Unexpectedly, activation of p21, ICAM1, or SRXN1 was not observed (Supplementary Figure S5), although DNA (Nassini et al., 2010), and Keap1 ( Figure 6 ) is consistent with the lack of activation of an adaptive oxidative stress response pathway observed here and in a previous study (Tafazoli and OBrien, 2009)

(Definition/Background Information) Melanotic macules are dark spots that may be observed on the skin, mucus membranes of the mouth, genitalia, and in the nails

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Chen Y, Yang SH, Zheng W, Zu RW, Ran SY, Wu H, et al