The findings suggest a significant enhancement in the antidepressant effect of LLP and APS following their combination, potentially through the modulation of brain 5-HT levels and suppression of HPA axis-induced stress, leading to activation of the AC/cAMP/PKA signaling pathway and upregulation of BDNF levels
Yang J, Li M-X, Luo Y, Chen T, Liu J, Fang P, et al
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Opioids are natural, semi-synthetic, or synthetic molecules that interact with opioid receptors
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