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298 On the other hand, a randomized controlled trial in 70 NAFLD patients found 500 mg curcumin and related curcuminoids plus 5 mg piperine per day for 12 weeks resulted in greater reduction in liver steatosis severity, assessed using ultrasound technology, than placebo

NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver