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Frostbite can occur at temperatures just below freezing (-0.55C or 31.01F), though at such temperatures frostbite is typically mild and no permanent damage will result

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Weight regain and appetite rebound are well-documented

The FDA prescribing information specifies the approved population as adults with a BMI of 30 or greater, or 27 or greater with at least one weight-related condition such as hypertension, type 2 diabetes, or dyslipidemia [2]