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With appetite suppressed, GLP-1 users need to be hyper-focused on ensuring that what they do eat and drink provides the right nutrition

Normally, the epithelium provides a natural barrier to the systemic invasion of bacteria, but this barrier is compromised as large areas of the epidermis become detached

In the process of hepatocellular steatosis, one of the hallmarks of MASLD is the appearance of the UPR in hepatocytes, which can inhibit mitochondrial lipid oxidation through the UPR-induced ATF-6 pathway and promote fatty acid synthesis via the PERK, ATF-6 and IRE1 signaling pathways, which together promote intracellular lipid accumulation (67,68)

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