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10.1371/journal.pone.0166125 180 TahraniA

A lysine at position 28 is switched out for an arginine, which leaves another lysine at position 26 free to be modified with a long fatty-acid/ethylene glyol-like chain, which improves the drugs half-life in the blood even more (by binding to serum albumin)

When semaglutide or other GLP-1 agonists bind to these receptors, they may modulate activity in the amygdala, prefrontal cortex, and hypothalamusareas critical to emotional processing and cortisol secretion

10.1159/000479257 48 RutebemberwaE.LubegaM.KatureebeS