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Here we will discuss relevant supplements that can actually dramatically reduce insulin resistance and can safely be used with metformin (or GLP-1 agonists)

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Some patients report fatigue during tirzepatide treatment, particularly during the early treatment phase or with dose escalation, though this is not among the most common adverse events in clinical trials

[1] [2] Individual gastrointestinal sensitivity: Patients with pre-existing gastrointestinal conditions such as gastroparesis, irritable bowel syndrome, or functional dyspepsia may experience earlier and more severe symptoms

While some patients have reported this, its rare and doesnt stem from the medication itself